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https://www.dailymail.co.uk/health/article-11323677/Outrage-Boston-University-CREATES-Covid-strain-80-kill-rate.htmlEXCLUSIVE: 'This is playing with fire - it could spark a lab-generated pandemic': Experts slam Boston lab where scientists have created a new deadly Covid strain with an 80% kill rate Researchers added Omicron's spike protein to the original Wuhan Covid strain
Omicron's spike is highly mutated which made it the most infectious variant ever
Eight in 10 mice infected with the lab-created strain died at Boston University lab
By Caitlin Tilley, Health Reporter For Dailymail.Com and Mansur Shaheen Deputy Health Editor For Dailymail.Com
Published: 11:02 EDT, 17 October 2022 | Updated: 05:00 EDT, 18 October 2022
DailyMail.com revealed the team had made a hybrid virus — combining Omicron and the original Wuhan strain — that killed 80 per cent of mice in a study.
The revelation exposes how dangerous virus manipulation research continues to go on even in the US, despite fears similar practices may have started the pandemic.
Professor Shmuel Shapira, a leading scientist in the Israeli Government, said: 'This should be totally forbidden, it's playing with fire.'
Gain of function research - when viruses are purposefully manipulated to be more infectious or deadly - is thought to be at the center of Covid's origin.
A Chinese laboratory located just miles from the first cluster of cases carried out similar research on bat coronaviruses.
But the practice has been largely restricted in the US since 2017.
Dr Richard Ebright, a chemist at Rutgers University in New Brunswick, New Jersey, told DailyMail.com that: 'The research is a clear example of gain of function research.
He added: 'If we are to avoid a next lab-generated pandemic, it is imperative that oversight of enhanced potential pandemic pathogen research be strengthened.'
In the new research , which has not been peer-reviewed, a team of researchers from Boston and Florida extracted Omicron's spike protein — the unique structure that binds to and invades human cells. It has always been present but it has become more evolved over time. Omicron has dozens of mutations in its spike protein that made it so infectious. Researchers attached Omicron's spike protein to the original wildtype strain that first emerged in Wuhan at the start of the pandemic. The researchers looked at how mice fared under the new hybrid strain compared to the original Omicron variant
Boston University's National Emerging Infectious Diseases Laboratories is one of 13 biosafety level 4 labs in the US
The most dangerous type of research can be carried out in these labs, involving highly infectious viruses such as Covid and Ebola
In biosafety 4 labs, researchers do all experiments in a ‘biosafety cabinet’ — an enclosed, ventilated workspace for handling materials contaminated with pathogens
Full-body, air-supplied pressure suits are worn and workers must change their clothing before entering and shower before leaving
80 percent of mice died from the new man-made Covid strain, while none died from the milder Omicron variant alone, researchers at Boston University's National Emerging Infectious Diseases Laboratories found
Dr Richard Ebright (left), a Rutgers University chemist, said that this research could spark the next lab-created pandemic. Professor Shmuel Shapira (right), a leading scientist in the Israeli Government, said that this type of research should be banned as it is playing with fire.
In the new research, which has not been peer-reviewed, a team of researchers from Boston and Florida extracted Omicron's spike protein — the unique structure that binds to and invades human cells.
It has always been present in the virus but has become more evolved over time. Omicron has dozens of mutations on its spike protein that made it so infectious.
Researchers attached Omicron's spike to the original wildtype strain that first emerged in Wuhan at the start of the pandemic.
The researchers looked at how mice fared against the new hybrid strain compared to the original Omicron variant.
When a similar group of rodents were exposed to the standard Omicron strain, however, they all survived and only experienced 'mild' symptoms.
Writing in the paper, they said: ‘In...mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80 percent.’
The researchers said it signaled that while the spike protein is responsible for infectivity, changes to other parts of its structure determine its deadliness.
The question of whether the global outbreak began with a spillover from wildlife sold at the market or leaked out of the Wuhan lab just eight miles across the Yangtze River has given rise to fierce debate about how to prevent the next pandemic. New studies point to a natural spillover at the Huanan wildlife market. Positive swab samples of floors, cages and counters also track the virus back to stalls in the southwestern corner of the market (bottom left), where animals with the potential to harbor Covid were sold for meat or fur at the time (bottom right)
Dr Ebright told DailyMail.com: 'The research is a clear example of gain of function research of concern and enhanced potential pandemic pathogen (ePPP) research.
'It is especially concerning that this new US-government ePPP research - like the previous US-government ePPP research on chimeric SARS-related coronaviruses at Wuhan Institute of Virology that may have caused the pandemic - appears not to have undergone the prior risk-benefit review mandated under US-government policies.
'If we are to avoid a next lab-generated pandemic, it is imperative that oversight of ePPP research be strengthened.
'It is imperative that the existing polices mandating prior risk-benefit assessment of ePPP research be followed, and it is imperative that officials at US-government agencies who repeatedly have placed the public at risk by repeatedly violating the existing policies be held accountable.'
Prof David Livermore, a professor of microbiology at the UK's University of East Anglia told DailyMail.com: 'given the strong likelihood that the Covid pandemic originated from the escape of a lab-manipulated coronavirus in Wuhan, these experiments seem profoundly unwise.'
Gain of function research was largely restricted in the US until 2017, when the National Institutes of Health began to allow it to take place using government funds.
Previously it had been halted from 2014 to 2017 over concerns that it could lead to the inadvertent creation of a pandemic.
The research involves tinkering with viruses to make them more lethal or infectious - with the hopes of getting ahead of a future outbreak.
The University of Boston refuted that the experiments are gain of function, adding that the research was reviewed and approved by the Institutional Biosafety Committee (IBC) and the Boston Public Health Commission.
A spokesperson said: 'This research mirrors and reinforces the findings of other, similar research performed by other organizations.
'Ultimately, this research will provide a public benefit by leading to better, targeted therapeutic interventions to help fight against future pandemics.'
While Covid is officially believed to have been transmitted from an animal to a human - likely from a bat - in a Wuhan wet market, some speculate otherwise.
The Wuhan Institute of Virology (WIV) was performing gain of function research on similar strains before the virus emerged in the city.
Some believe that the pathogen being developed in the lab infected employees, and escaped into the world as a result.
The Boston scientists were performing similar research, and looked at different strains' effect on human lung cells that were grown in the lab.
Covid latches onto human cells with its spike protein, and instructs healthy cells to produce copies of itself.
Scientists measured how many copies each variant caused the health cells to produce.
They found the hybrid strain produced five times more viral particles than the original Omicron.
The scientists admit the hybrid virus is unlikely to be as deadly in humans as it was in mice.
This is because the specific breed of lab mice used are very susceptible to severe Covid disease. Mice and humans also have very different immune responses to the virus.
The lab, at Boston University's National Emerging Infectious Diseases Laboratories, is one of 13 biosafety level 4 labs in the US.
These are labs that are authorized to handle the most dangerous pathogens. There are also facilities in Texas, Atlanta and Manhattan, Kansas.
Experiments at these labs often involve tinkering with animal viruses to advance treatments and vaccines that could be used in a future outbreak.
Work on the live virus that causes Covid must be carried out at a BSL-3 or BSL-4 lab.
In BSL-3 labs, researchers do all experiments in a ‘biosafety cabinet’ — an enclosed, ventilated workspace for handling materials contaminated with pathogens.
The labs also have self-closing doors, sealed windows, floors and walls, and filtered ventilation systems.
In a BSL-4 lab, full-body, air-supplied pressure suits are worn and workers must change their clothing before entering and shower before leaving.
The lab is situated in a separate section of the building and has its own dedicated air supply.
There have long been speculation about the true origins of the virus that took over the world in early 2020.
Officially, it is believed that the virus was transmitted from a bat or similar animal to a human in Wuhan, before spreading among people.
Some believe that the virus could be man-made - with explanations ranging from the accidental to the nefarious.
The 'lab leak' Covid theory alleges that the virus was created via gain of function research being undertaken at the WIV.
It is feared that the virus being developed managed to infect an employee and then escape into the real world from there.
The theory for Covid was initially dismissed as conspiracy at the start of the pandemic in favor of a natural emergence.
But the hypothesis gained momentum following a series of revelations and cover-ups.
Crucial information about the earliest infected patients was wiped from the Wuhan lab's database in late 2019 and one of its staff vanished after coming down with a mysterious flu-like illness.
Fierce debate about the origins of the Covid pandemic was reignited after two studies claimed to trace the outbreak back to a notorious animal slaughter market in Wuhan.
One shows for the first time how the earliest human cases were clustered within a small radius around the Huanan Seafood Market in winter 2019.
More precise analysis of swabs taken from floors, cages and counters track the virus back to stalls in the southwestern corner of the market, where animals that can harbor Covid were sold for meat or fur at the time.
A second study claims to have pinpointed the exact date the first animal-to-human infection occurred — November 18, 2019 — after carrying out genetic analysis on hundreds of samples from the first human carriers.
They also say they have found evidence another first generation strain was spreading at the wet market — which, if true, would place both original lineages within its walls.
Until recently, the only Covid cases linked to the market were Lineage B, which was thought to have evolved after Lineage A.
Proponents of the accidental lab leak hypothesis used this as proof the virus only arrived at the market after evolving elsewhere in Wuhan.
