Author Topic: Patients with Vit D deficiency twice as likely to experience major complications  (Read 3484 times)

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Please read the important disclaimer at the following link before proceeding further on this page. The administrator of this forum is not a doctor nor licensed or experienced in any aspect of the health care industry. That's why we depend on world leading epidemiologists, virologists, microbiologists, immunologists and vaccinologists, but most importantly front line treating physicians that have been in the trenches curing COVID patients ever since the pandemic began.
https://www.covid-19forum.org/index.php?topic=227.0

[edit add 10-20-2023] With caution:
Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761047/ [end edit]

[edit add 8-21-22] Excellent site on vitamin D
Grass Roots Health
https://www.grassrootshealth.net/?s=vitamin+D [end edit]

"Despite health agencies and organizations publishing daily intake guidelines for these and other vitamins and nutrients, researchers at Oregon State University estimate that 94% of people older than 4 in the United States have less-than-adequate levels of vitamin D.
https://www.upi.com/Health_News/2020/10/27/Vitamin-deficiencies-linked-to-respiratory-conditions-including-COVID-19/9491603827437/

Added video on 4-18-21
When YouTube bans the video at the link below you can access it at this BitChute video that also has the unrelated second half edited out:
https://www.bitchute.com/video/i3rlgX5MtyfK/



App to let you know when to soak up vitamin D naturally
http://dminder.ontometrics.com/
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https://c19vitamind.com/ Click on link for latest additional studies



https://c19vitamind.com/
excerpts from just the first few studies:

"Prospective study of 91 asymptomatic and 63 ICU patients showing significantly higher vitamin D deficiency in the ICU patients (97% vs. 33%).

Retrospective 335 patients in China compared to 560 matched controls showing significanlty lower risk of severe COVID-19 with vitamin D sufficiency (>=30 nmol/L) OR 0.37, p = 0.014.

Mathematical analysis of Córdoba calcifediol trial suggests strong role for Vitamin D in reducing ICU admissions of hospitalized COVID-19 patients

53% reduction in PCR+ with high-dose cholecalciferol supplementation. RCT with 16 treatment patients and 24 control patients.

Retrospective study finding that regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.

Vitamin D3 supplementation during or just before COVID-19 was associated with 68% lower mortality and less severe COVID-19 in frail elderly.

Retrospective 235 hospitalized patients showing a significant association between vitamin D sufficiency and reduction in clinical severity."

etc. etc. https://c19vitamind.com/

[added video 6-28-21]


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https://www.sciencedaily.com/releases/2020/05/200507121353.htm

Vitamin D levels appear to play role in COVID-19 mortality rates
Patients with severe deficiency are twice as likely to experience major complications


Date:  May 7, 2020
Source:  Northwestern University
Summary:  Researchers analyzed patient data from 10 countries. The team found a correlation between low vitamin D levels and hyperactive immune systems. Vitamin D strengthens innate immunity and prevents overactive immune responses. The finding could explain several mysteries, including why children are unlikely to die from COVID-19.

After studying global data from the novel coronavirus (COVID-19) pandemic, researchers have discovered a strong correlation between severe vitamin D deficiency and mortality rates.

Led by Northwestern University, the research team conducted a statistical analysis of data from hospitals and clinics across China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the United Kingdom (UK) and the United States.

The researchers noted that patients from countries with high COVID-19 mortality rates, such as Italy, Spain and the UK, had lower levels of vitamin D compared to patients in countries that were not as severely affected.

This does not mean that everyone -- especially those without a known deficiency -- needs to start hoarding supplements, the researchers caution.

"While I think it is important for people to know that vitamin D deficiency might play a role in mortality, we don't need to push vitamin D on everybody," said Northwestern's Vadim Backman, who led the research. "This needs further study, and I hope our work will stimulate interest in this area. The data also may illuminate the mechanism of mortality, which, if proven, could lead to new therapeutic targets."

The research is available on medRxiv, a preprint server for health sciences.

Backman is the Walter Dill Scott Professor of Biomedical Engineering at Northwestern's McCormick School of Engineering. Ali Daneshkhah, a postdoctoral research associate in Backman's laboratory, is the paper's first author.

Backman and his team were inspired to examine vitamin D levels after noticing unexplained differences in COVID-19 mortality rates from country to country. Some people hypothesized that differences in healthcare quality, age distributions in population, testing rates or different strains of the coronavirus might be responsible. But Backman remained skeptical.

"None of these factors appears to play a significant role," Backman said. "The healthcare system in northern Italy is one of the best in the world. Differences in mortality exist even if one looks across the same age group. And, while the restrictions on testing do indeed vary, the disparities in mortality still exist even when we looked at countries or populations for which similar testing rates apply.

"Instead, we saw a significant correlation with vitamin D deficiency," he said.

By analyzing publicly available patient data from around the globe, Backman and his team discovered a strong correlation between vitamin D levels and cytokine storm -- a hyperinflammatory condition caused by an overactive immune system -- as well as a correlation between vitamin D deficiency and mortality.

"Cytokine storm can severely damage lungs and lead to acute respiratory distress syndrome and death in patients," Daneshkhah said. "This is what seems to kill a majority of COVID-19 patients, not the destruction of the lungs by the virus itself. It is the complications from the misdirected fire from the immune system."

This is exactly where Backman believes vitamin D plays a major role. Not only does vitamin D enhance our innate immune systems, it also prevents our immune systems from becoming dangerously overactive. This means that having healthy levels of vitamin D could protect patients against severe complications, including death, from COVID-19.

"Our analysis shows that it might be as high as cutting the mortality rate in half," Backman said. "It will not prevent a patient from contracting the virus, but it may reduce complications and prevent death in those who are infected."

Backman said this correlation might help explain the many mysteries surrounding COVID-19, such as why children are less likely to die. Children do not yet have a fully developed acquired immune system, which is the immune system's second line of defense and more likely to overreact.

"Children primarily rely on their innate immune system," Backman said. "This may explain why their mortality rate is lower."

Backman is careful to note that people should not take excessive doses of vitamin D, which might come with negative side effects. He said the subject needs much more research to know how vitamin D could be used most effectively to protect against COVID-19 complications.

"It is hard to say which dose is most beneficial for COVID-19," Backman said. "However, it is clear that vitamin D deficiency is harmful, and it can be easily addressed with appropriate supplementation. This might be another key to helping protect vulnerable populations, such as African-American and elderly patients, who have a prevalence of vitamin D deficiency."

Backman is the director of Northwestern's Center for Physical Genomics and Engineering and the associate director for Research Technology and Infrastructure at the Robert H. Lurie Comprehensive Cancer Center at Northwestern University."
« Last Edit: October 20, 2023, 05:20:38 PM by admin »
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Immunologic Effects of Vitamin D on Human Health and Disease
https://pubmed.ncbi.nlm.nih.gov/32679784/
« Last Edit: October 19, 2020, 06:03:02 AM by admin »
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https://www.bostonherald.com/2020/09/17/vitamin-d-can-help-reduce-coronavirus-risk-by-54-boston-university-doctor/

"Vitamin D can help reduce coronavirus risk by 54%: Boston University doctor
The sunshine vitamin is easy to find and relatively cheap

By Alexi Cohan
PUBLISHED: September 17, 2020

Stop waiting for a miracle drug: A Boston University doctor says a sufficient amount of vitamin D can cut the risk of catching coronavirus by 54%.

“People have been looking for the magic drug or waiting for the vaccine and not looking for something this simple,” said Dr. Michael Holick, professor of medicine, physiology and biophysics at Boston University School of Medicine.

Holick and his colleagues studied blood samples from Quest Diagnostics of more than 190,000 Americans from all 50 states and found that those who had deficient levels of vitamin D had 54% higher COVID positivity compared to those with adequate levels of vitamin D in the blood.

The risk of getting coronavirus continued to decline as vitamin D levels increased,
the study, published in the Public Library of Science One peer-reviewed journal shows.

“The higher your vitamin D status, lower was your risk,” Holick said.

Many people are vitamin D-deficient because there are only small amounts in food, Holick said. Most vitamin D comes from sun exposure and many are deprived, especially during winter months.

But the sunshine vitamin is easy to find and relatively cheap in drug stores, and taking vitamin D pills comes at no risk. “It’s perfectly safe,” Holick said.

“It’s considered to be, by many, the nutrient of the decade,” Holick said.

COVID-19 positivity is strongly associated with vitamin D levels in the blood, a relationship that stayed the same across different races, sexes and age ranges, the study states.

Vitamin D suppresses excessive cytokine release that can present as a cytokine storm, a common cause of COVID-related morbidity and mortality.

A deficiency in the nutrient alters the immune system, making one more likely to get upper respiratory infections, Holick said.

Throughout the pandemic, people of color have been disproportionately affected by coronavirus, experiencing a higher risk of acquiring it and having serious complications, according to the Centers for Disease Control.

Holick’s study examined the ZIP codes of people of color and found patients from predominantly Black and Hispanic ZIP codes had lower levels of vitamin D and were also more likely to have coronavirus than in patients from predominantly white, non-Hispanic ZIP codes.

The average adult needs around 2,000 units of vitamin D a day, Holick said. He said he’s been taking 6,000 units a day for decades and is in great health.

Several other studies on vitamin D have shown its benefits to the immune system.

Research published with the National Institutes of Health showed people with lower vitamin D levels were more likely to self-report a recent upper respiratory tract infection than those with sufficient levels.

Another study of more than 11,000 participants published in the British Medical Journal found vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants.

“Vitamin D definitely improves your overall immunity to fight infections,” Holick said.
« Last Edit: December 25, 2020, 07:15:29 AM by admin »
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"What is vitamin D toxicity? Should I be worried about taking supplements? Answer From Katherine Zeratsky, R.D., L.D.

Vitamin D toxicity, also called hypervitaminosis D, is a rare but potentially serious condition that occurs when you have excessive amounts of vitamin D in your body.

Vitamin D toxicity is usually caused by large doses of vitamin D supplements — not by diet or sun exposure. That's because your body regulates the amount of vitamin D produced by sun exposure, and even fortified foods don't contain large amounts of vitamin D.

The main consequence of vitamin D toxicity is a buildup of calcium in your blood (hypercalcemia), which can cause nausea and vomiting, weakness, and frequent urination. Vitamin D toxicity might progress to bone pain and kidney problems, such as the formation of calcium stones.

Treatment includes stopping vitamin D intake and restricting dietary calcium. Your doctor might also prescribe intravenous fluids and medications, such as corticosteroids or bisphosphonates.

Taking 60,000 international units (IU) a day of vitamin D for several months has been shown to cause toxicity. This level is many times higher than the U.S. Recommended Dietary Allowance (RDA) for most adults of 600 IU of vitamin D a day.

Doses higher than the RDA are sometimes used to treat medical problems such as vitamin D deficiency, but these are given only under the care of a doctor for a specified time frame. Blood levels should be monitored while someone is taking high doses of vitamin D.

As always, talk to your doctor before taking vitamin and mineral supplements."

https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-d-toxicity/faq-20058108

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https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab405/6294179

"ICU assistance was required by 102 (12.2%) participants. Out of 447 patients treated with calcifediol at admission, 20 (4.5%) required ICU, compared to 82 (21%) out of 391 non-treated (p-value<0.0001)."
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"COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

Background
Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

Conclusions
The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity."

https://www.medrxiv.org/content/10.1101/2021.09.22.21263977v1
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Lot of information on vitamin D
Grass Roots Health
https://www.grassrootshealth.net/?s=vitamin+D [end edit]
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Over a million Americans died completely unnecessary, horrific, deaths from COVID-19. Do you have a plan in place to help your family dodge the average $73,300 COVID hospital bill, through prevention and $20 EARLY treatment? https://www.covidtreatment

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https://articles.mercola.com/sites/articles/archive/2022/12/02/new-study-vitamin-d-combating-covid.aspx?ui=0878ac11701e131c309e506df5f8e1cc6779cc368fc6f8e802f9b3a45e299881&sd=20210809&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20221130&cid=DM1296582&bid=1657626706

"New Study on Vitamin D Combating COVID
Analysis by Dr. Joseph Mercola

Story at-a-glance

    Researchers from Johns Hopkins University, the University of Chicago and the Department of Veterans Health Affairs conducted a large-scale pharmacoepidemiologic study of the association between vitamin D and COVID-19 infection and mortality
    Those who took vitamin D2 supplements had a 28% lower risk of COVID-19 infection, while those taking vitamin D3 had a 20% lower risk
    Death from COVID-19 was also lower among those taking vitamin D — 33% lower among those taking vitamin D3 and 25% lower among those taking vitamin D2
    If the entire U.S. population in 2020 had supplemented with vitamin D3, it would have prevented 4 million COVID-19 cases and 116,000 deaths
    I strongly recommend getting your vitamin D from proper sun exposure if possible, as it will provide numerous other benefits, many of which are only beginning to be understood"

https://articles.mercola.com/sites/articles/archive/2022/12/02/new-study-vitamin-d-combating-covid.aspx?ui=0878ac11701e131c309e506df5f8e1cc6779cc368fc6f8e802f9b3a45e299881&sd=20210809&cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20221130&cid=DM1296582&bid=1657626706
« Last Edit: December 02, 2022, 07:44:50 AM by admin »
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bump
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Over a million Americans died completely unnecessary, horrific, deaths from COVID-19. Do you have a plan in place to help your family dodge the average $73,300 COVID hospital bill, through prevention and $20 EARLY treatment? https://www.covidtreatment