https://pubmed.ncbi.nlm.nih.gov/28479213/2017 Sep;83:12-21.
doi: 10.1016/j.jaut.2017.04.008. Epub
May 5, 2017.
Original antigenic sin: A comprehensive reviewAnup Vatti 1 , Diana M Monsalve 2 , Yovana Pacheco 2 , Christopher Chang 1 , Juan-Manuel Anaya 2 , M Eric Gershwin 3
Abstract
The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed. Antigenic sin has been demonstrated to occur in several infectious diseases in both animals and humans, including human influenza infection and dengue fever. The basis of "original antigenic sin" requires immunological memory, and our immune system ability to autocorrect. In the context of viral infections, it is expected that if we are exposed to a native strain of a pathogen, we should be able to mount a secondary immune response on subsequent exposure to the same pathogen. "Original antigenic sin" will not contradict this well-established immunological process, as long as the subsequent infectious antigen is identical to the original one. But "original antigenic sin" implies that when the epitope varies slightly, then the immune system relies on memory of the earlier infection, rather than mount another primary or secondary response to the new epitope which would allow faster and stronger responses.
The result is that the immunological response may be inadequate against the new strain, because the immune system does not adapt and instead relies on its memory to mount a response. In the case of vaccines, if we only immunize to a single strain or epitope, and if that strain/epitope changes over time, then the immune system is unable to mount an accurate secondary response. In addition, depending of the first viral exposure the
secondary immune response can result in an antibody-dependent enhancement of the disease or at the opposite, it could induce anergy. Both of them
triggering loss of pathogen control and inducing aberrant clinical consequences."
https://pubmed.ncbi.nlm.nih.gov/28479213/______________________________________________
All COVID-19 "vaccinations" that have been administered were designed to reduce the severity of symptoms of the original A/B strains of the SARS-CoV-2 virus, that do not exist anymore, because they were displaced by the Delta strain. So COVID vaccines are obsolete and when it comes to the Delta variant, have far lower efficacy, exacerbated by the fact that they have proven to not be durable since immunity wanes quite rapidly. In the case of the J&J-Janssen vaccine for example, according to one recent large veteran study, from 88% to 3% effective in just 6 months.
But the problem may be worse than the vaccine just being obsolete with rapidly vanishing efficacy. Using these obsolete vaccines may actually compromise the immune systems of those that received them, rendering them less able to fight the delta or other strains of COVID-19 infection that are yet to come along, because of Original Antigenic Sin. While previously infected and recovered person's immunity remains robust, durable and long-lasting, for natural immunity against the original A/B strains of the SARS-CoV-2 virus, as well as its variants.
Thus, since around June/July in the U.S. and much earlier in Europe, let alone India where the delta variant originated,
"vaccination" may well have been putting recipients at increasing risk of harm from COVID-19 as immunity from the "vaccine's" wanes. In essence, in addition to the giant litany of "vaccine" associated risks, our government and employers are now forcing people to risk compromising their immune system's ability to fight the delta variant and later strains of COVID-19 or a simple case of seasonal flu, at least after some point during their "vaccine's" waning efficacy.
3:16:00 mark in this video
https://globalcovidsummit.org/news/breaking-watch-florida-physicians-summit-livestreamHere's a more lay explanation from Wikipedia.
https://en.wikipedia.org/wiki/Original_antigenic_sin"Original antigenic sin, also known as antigenic imprinting or the Hoskins effect,[1] refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.
The phenomenon of original antigenic sin has been described in relation to influenza virus, SARS-CoV-2,[2] dengue fever, human immunodeficiency virus (HIV) [3] and to several other viruses.[4]
This phenomenon was first described in 1960 by Thomas Francis Jr. in the article "On the Doctrine of Original Antigenic Sin".[5][6] It is named by analogy to the theological concept of original sin. According to Francis as cited by Richard Krause:[6]
"The antibody of childhood is largely a response to dominant antigen of the virus causing the first type A influenza infection of the lifetime. [...] The imprint established by the original virus infection governs the antibody response thereafter. This we have called the Doctrine of the Original Antigenic Sin.""
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https://wentworthreport.com/2021/10/27/original-antigenic-sin-and-the-folly-of-our-universal-vaccination-campaign/"
Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign."Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign. By Eugyppius.
We have now had ten months of mass vaccination against SARS-CoV-2. Nearly 7 billion doses have been administered worldwide. This unprecedented campaign has not eradicated Corona; it has not even suppressed infections. Instead, case statistics have ballooned almost everywhere. While the vaccinated appear to enjoy some protection against severe outcomes, skyrocketing transmission means most countries have seen little benefit, on balance, from their universal vaccination campaigns. The most pressing question has become, simply: What is going on?
Original antigenic sin:
The Public Health England data provide powerful reasons to suspect that the vaccines may be compromising immunity to SARS-2 via Original Antigenic Sin. This is not a crazy internet fantasy, but a well-observed limitation of human immunity. It is the primary reason that respiratory viruses like influenza return again and again. Despite multiple reinfections across the whole population, we are never quite immune to the flu, because its strategy is to exploit the way our immune systems learn.
The mechanisms of Original Antigenic Sin are not fully understood, but we have a rough idea of what might be happening. When a virus infects your body for the first time, your naive memory B cells imprint on specific virus proteins, or antigens, presented to them. These B cells then become either memory B cells or plasma cells. Forever after, they specialize in producing antibodies against those specific antigens.
When a slightly mutated form of the virus arrives, these memory B-cells begin pouring forth the antibodies they learned to produce during the first infection. These antibodies bind to multiple epitopes on the virus particles, and in the process they give the slower-moving naive B-cells little chance to learn about any new, mutant virus features."
More on this subject.
https://duckduckgo.com/?q=original+antigenic+sin&t=h_&ia=web
