https://www.cuimc.columbia.edu/news/bivalent-booster-worth-it"Is the Bivalent Booster Worth It?
November 18, 2022"
"The booster’s efficacy in people had not been studied before the booster was approved by the FDA, though animal studies have found it generates better protection against widely circulating omicron variants.
Statements in the past weeks from vaccine manufacturers maintain that the bivalent booster is better than the original booster at increasing antibodies. But an unpublished study conducted by David Ho, MD, director of the Aaron Diamond AIDS Research Center at Columbia University Vagelos College of Physicians and Surgeons, suggests that the new bivalent booster generates the same level of antibodies against omicron variants as the original booster. Harvard researchers have reported similar results. (The
Columbia(link is external and opens in a new window) and
Harvard(link is external and opens in a new window) studies are available as preprints on BioRxiv)."
"Our result was a bit disappointing, because we all wanted to see the bivalent booster generate a superior antibody response against omicron, but our human data show that there’s not a lot of difference between the two types."
